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Research priorities for other prevalent types of problem-solving courts, including DWI courts, juvenile drug courts and family dependency treatment courts. Standardized Performance Indicators and Model Evaluation Plans The NRAC also met on several occasions in 2005 to develop a "logic model" and standardized performance indicators for drug court program evaluations. This culminated in a document Cary, in press ; on standardized data elements for drug courts that has been very well received by the U.S. Department of Justice's Bureau of Justice Assistance BJA ; . We are awaiting approval from BJA to publish that document, entitled "Local Drug Court Research: Navigating Performance Measures and Process Evaluations." NRAC will continue this work in 2006 by addressing: Standardized data elements for other problem-solving courts, including juvenile drug courts, DWI courts and family dependency treatment courts; Identification of appropriate comparison groups Development of model evaluation plans; and Development of model automated data collection strategies.
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TITLE The influence of a communication-orientated educational workshop on the interaction between nursing home staff and persons with Alzheimer's disease AD ; in a nursing home setting. RESEARCHER SUPERVISOR CO-SUPERVISOR DEPARTMENT DEGREE Nicolene Schoeman Dr Odette Guy and Mrs Alex Stipinovich Mr Herman Tesner Communication Pathology, University of Pretoria M munication Pathology.
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Gillnets 86 % ; and pole and line 46 % ; to catch 68 fish species common names ; , mostly tucunare, Cichla spp. 67 % ; , curimat, Prochilodus nigricans 65 % ; , pescada, Plagioscion squamosissimus 54 % ; and piranhas, Pygocentrus nattereri and Serrasalmus spp. 45 % ; . Most fishers use to sell the fish 85 % ; in their own communities 59 % ; . Fishers mentioned 170 fishing grounds exploited. According to them, May 36 %, receding waters ; and the dry season 21 %, July to September ; are the best times of the year for fishing. Most fishers 53 % ; mentioned that no fish had its abundance increased after the reservoir's formation, but there was a decrease in the abundance of 75 fish species, the most cited ones were the jaraqui, Semaprochilodus brama 69 % ; , the pratiqueira, Characidade 38 % ; , the pirapitinga, Piaractus brachypomum 25 % ; and the pirabanha, Brycon sp. 25 % ; . The majority of fishers 62 % ; mentioned the decrease in fish catches as the main environmental change caused by the reservoir. These useful data based on a rapid survey of fishers' knowledge will be compared to data from Eletronorte surveys, in order to improve the fisheries research and management in the Tocantins River. This approach might be useful to several other still poorly known small-scale tropical fisheries. * Research project financed by ELETRONORTE Aneel 4500057477 ; , FAURGS UFRGS, Unicamp, INPA II.2.6 Preliminary data about common snook Centropomus undecimalis ; : ethnoecology at Natal, RN Brazil ; * C. de M. Martinelli1 and A. Begossi2.
There is evidence that MOE considered the economic impacts of more stringent standards for tritium discharge to be significant in its decision to adopt the Canadian guidelines. An internal MOE report suggested that the costs of meeting a more stringent standard were prohibitive, and the increased health benefits associated with a tougher standard would be insignificant. The estimate for complying with a 20 Bq weekly average was 0 million in initial equipment redesign and possibly billions thereafter for maintenance, etc. MOE also estimated that out of the estimated 3 million people living near the nuclear plants. there would only be an additional 2.4 deaths during a 70-year period from fatal cancers associated with a yearly average tritium releases of 100 Bq l. Today tritium concentrations measured at water supply plants around Darlington have gone as high as 25 Bq L, but are typically in the range of 510 Bq l. In the absence of further atmospheric detonations of nuclear weapons the major source for radiation in drinking water ; , chronic tritium levels in drinking water are expected to remain below 100 Bq L. One rationale for adopting a higher standard is that it allows for short-term spikes that have been shown to have no biological consequences. MOE also considered the economic impact of imposing stricter screening levels for gross alpha and beta radioactivity. After considering the comments from the Ontario Ministry of Labour, they decided to maintain current levels. This is contrary to the Canadian Guideline, which recommends screening levels of 0.1 Bq l for gross alpha radiation and 1 Bq l for gross beta radiation. The Canadian guidelines do take into account natural sources of radionuclides in their guideline limits. This is in line with the SEV for MOE, which requires the consideration of other media and sources. Other Information: MOE posted a related exception on April 5, 1995, to lower the Ontario Drinking Water Objective for tritium from 40, 000 to 7, 000 Bq L. The decision to establish this objective received many applications for review in 1995 and a comment on this issue was included in the 1995 ECO Annual Report. The Ontario government announced a new Drinking Water Protection Regulation as part of the Water Resources Act in August 2000. This converts the Ontario Drinking Water Objectives into Drinking Water Standards and gives them the force of law. It is hoped that this measure will improve the enforcement of drinking water quality in the province. ECO Comment: Description of the Decision The decision notice is technical and difficult to understand. Many complex scientific terms were used and none of them were defined or explained. While it may be challenging to explain specialized words and phrases, MOE should use plain language so that the public can understand such a proposal. The original intent was to adopt the national guidelines as objectives, but by the time the decision was and bilberry.
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| Betaxolol hcl ophthalmic solutionJoseph Rajendran et al radio-conjugate. Other problems of RIT include 1 ; delivery issues, 2 ; immunogenicity, and 3 ; stability of the conjugate. The problems associated with using whole antibodies have prompted research involving a variety of antibody fragments to increase uptake in the tumor while resulting in rapid clearance from blood to produce an optimal therapeutic ratio. Fragments of the antibody are now available; from simple cleaved fragments such as F ab' ; 2 and Fab' 3 ; to engineered fragments such as single chain Fv sFv ; and divalent sFv 4, 5 ; . However, in spite of the concerted efforts in applying RIT to all solid tumors, it has been found to be most successful only in patients with B-cell malignancies such as NHL 6, 7 ; . B cell tumors have an abundant expression of antigens such as CD20 and CD19 that are attractive targets for radioimmunotherapy 8 ; . Immunogenicity of the administered antibody can be another impediment in some patients, especially when mouse produced monoclonal antibodies are used, requiring that the patients are tested for human anti mouse antibody HAMA ; prior to administration. Although humanized versions have been produced with the hope of avoiding this problem, one needs to be cautious about the production of human anti human antibody HAHA ; 9 ; . These antibodies would result in neutralizing the administered therapeutic antibodies. However, in spite of these possibilities, treated patients rarely show any significant toxicity. This is explicable by the already compromised immune function in many cancer patients and the use of adjuvant cytotoxic chemotherapy that is immunosuppressive by itself. In order to increase the tumor to background ratio and to reduce normal tissue toxicity, pre-targeting with a two-step or three-step methods using streptavidin, biotin and with or without a clearing agent have been tried. These methods, although making the process more complicated, can be expected to result in ideal tumor to background ratio 10, 11 ; . Another novel approach to reduce the circulating radioimmunoconjugate has been to use extra corporeal immune-adsorption, that uses a column located ex vivo, to remove redundant radioactivity from the blood 10 ; . Radio-immunoconjugates for RIT can be administered systemically or by intracavitary or intra-tumoral injections. The latter routes have been used to result in maximal delivery to the tumor in accessible sites such as the peritoneal cavity e.g. ovarian cancer ; or resection cavity e.g. glioblastoma ; . isotopes were identified and clinical uses explored largely due to advances in scientific research, systematic clinical trial design and consideration of the properties of radiopharmaceuticals. All radioisotopes used in therapy are emitters of particulate radiation, as they deposit all their energy within short distances in tissues. Pure particle emitters do not require special radiation safety precautions, permitting out-patient treatment but the presence of gamma emission is helpful in imaging and studying the bio-distribution of a particular radiopharmaceutical, for drug development and for dosimetry to estimate patient specific radiation absorbed dose. When pure particle emitters are used in therapy, internal dosimetry has been attempted using surrogate isotopes e.g. 1l1In for 90 Y 11 ; with the assumption of identical biological behavior in vivo for both agents. Emitters of Auger electrons, e.g. Indium - 111 and low energy electrons have also been investigated for treatment purposes 12 ; 13 ; The ultimate performance of a radio-immunoconjugate in the body depends not only on the properties of the radioisotope but also on the bio-kinetic properties of the conjugate. In general the physical half-life of the isotope should be longer than the time needed for targeting the tissue tumor aiming for a maximal tissue-to-background ratio. Radioisotopes with very short half-lives are often not desirable for labeling antibodies. In spite of these drawbacks, short lived isotopes, both alpha e12Bi and 213Bi ; and beta emitters 67CU ; , have been proposed in the treatment of acute leukemia 14 ; . Binding efficiency and stability of a Table 1: Showing physical characteristics of commonly used radioisotopes in radioimmunotherapy and bisacodyl.
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Bunolol, these observations were not confirmed by Student's t-tests between their ID50 values. From the study of delayed effects on cell proliferation, we found levobunolol to be the only drug that became less toxic after the cells were washed free of drug and recultured. Because benzalkonium chloride might contribute to the toxicity and the commercially available preparation of levobunolol contained 2.5fold less preservative than did those of betaxolol or timoptic, the cells that were exposed to levobunolol might have been more liable to recuperate from the initial injury than those exposed to the other drugs. Our study did not show any stimulation of fibroblast growth in subsequent cultures after they were exposed to these drugs. Our results do not agree with those of an earlier study16 that investigated the toxic effects of Betagan, Betoptic, and Timoptic on regenerating rabbit corneal epithelium. This study found that Timoptic was more toxic than either Betagan or Betoptic, despite the fact that Timoptic had the same benzalkonium chloride concentration as Betoptic 0.01% ; and a greater one than Betagan 0.04% ; . These discrepancies with our study may be caused by differences between an in vivo rabbit model and our in vitro tissue culture system, species differences between human and rabbit tissues, the fact that the other authors were studying regenerating corneal epithelium after it was damaged and we were studying healthy fibroblasts grown from human Tenon's capsule, or the possibility that an in vitro system studying sustained effects of drugs on tissue over many hours may not be sensitive enough to pick up differences manifested in vivo. The thymidine assay showed a greater range of ID50 determinations for the various 3-adrenergic blockers than did the hexosaminidase assay. A more direct and sensitive assay, it may have been influenced more by differences in cell lines, number of passages, and experimental variability. At the highest concentrations of commercially available preparations, we found cell death with preservation of cell morphology. At lower concentrations, we observed cell fragmentation and lysis. This was an unusual and unexpectedfinding.We postulate cell death may have occurred so rapidly at these higher drug concentrations that cell structure was preserved and fixed to the bottom of the wells without the shrinkage and shape deformation expected to occur during a slower cell death process at lower drug concentrations. In summary, there was a statistically significant difference in toxicity between a pure and commercially available preparation of timolol. The other pure preparations of 0-adrenergic blockers had similar toxicities. Except for levobunolol, which showed decreased and bleomycin.
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